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KMID : 0869619970140030227
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Journal of Korean Society of Hospital Pharmacists
1997 Volume.14 No. 3 p.227 ~ p.232
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Comparative Study on the Clinical Effectiveness of Lonazolac-Ca(Irritren^(®)) and Naproxen in the Control of Chronic Low Back Pain
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Abstract
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Chronic low back pain is a high-profile symptom in industrialized societies. To control chronic low back pain nonsteroidal anti-inflammatory drugs have been used so easily and widely. We investigated clinical effectiveness of a newly developed NSAID, Lonazolac-Ca(Irritren^(R)), and compared it to naproxen which has been used so long. We recommanded 50 chronic low back pain patients to take lrritren and Naproxen with double blind method. The patients have suffered from low back pain for more than 3 months and were not included in surgical indication. Irritren group was 27 patients and Naproxen group 23 patients. There was no significant statistical difference in age, symptom duration, and pre-medication functional status (ROM degree) between two drug groups. Total medication period was 33months(aberage 1.4 months). Back pain has much more improved in Irritren group (59%, 16 out of 27) than Naproxen group (35%, 8 out of 23), but statistically not significant. And degree of functional improvement also seemed to be larger in Irritren group than Naproxen group with Rom assessment (P=0.045). 10% of the patients showed gastrointestinal symptoms and hypersensitivity reaction but other serious side effects were not observed. So we concluded that these two drugs are useful and safe in the control of chronic low back pain.
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KEYWORD
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